Epidemiolody

 

HIV AIDS 

OUR understanding of disease mechanisms and cooperate to move novel HIV prevention and treatment strategies from basic research into clinical practice. BRTI conducts and supports a comprehensive program of basic, behavioral, clinical, and translational research on HIV/AIDS and its associated coinfections, comorbidities, and other complications.

Bridging the Gap in HIV testing and care for children in Zimbabwe

The aim of this project is to investigate two interventions aimed at improving uptake of HIV testing and engagement with HIV care for children aged 2 – 18 years.

BREATHE

A multi-site, individually randomised, double-blinded, placebo-controlled clinical trial. The trial aims to assess whether adjuvant treatment with azithromycin results in improvement in lung function in HIV-positive children with chronic lung disease.

FAST

Youth have the highest incidence of HIV in sub-Saharan Africa but the lowest rates of testing. The feasibility and acceptability of HIV self-testing in adolescents and young people (FAST) study will investigate whether self-testing using oral mucosal transudate tests could be a solution. 

Past Projects

Bridging the Gap in HIV testing and care for children in Zimbabwe

Child Aid

Development of a unique model of accessible HIV diagnostic services for children and teachers in a non-clinical setting. Strengthening HIV Prevention: HIV testing is an integral part of HIV prevention. CT will aid improve HIV knowledge among children,

ZIMPHIA

The Zimbabwe Population-Based HIV Impact Assessment (ZIMPHIA) began fieldwork in October 2015 and announced preliminary results in December 2016. In Zimbabwe— the first country to conduct a PHIA survey— survey teams visited over 11,000 households,

Tuberculosis  

Tuberculosis research studies are designed to answer important questions and to find out whether new approaches are safe and effective. Tuberculosis research already has led many advances, and researchers continue to search for more effective methods for dealing with tuberculosis. There are several current areas of focus for tuberculosis research, including: Diagnostics, treatment and vaccines

IRISA

To validate the novel in-vitro diagnostic(IVD) test for TB meningitis and determine its placement in a rapid diagnostic algorithm thereby increasing prospects for commercialisation.

Integrated Alcohol and Smoking Behavioural Interventions with TB Care for Improved TB Treatment outcomes in Zimbabwe

This 3,800 patient randomized controlled trial evaluates a low-cost behavioural intervention designed to aid smoking cessation and reductions in alcohol consumption among TB patients. The study will provide causal evidence on the impact of integrating such care on TB health outcomes, and aims to provide a scalable way to improve TB outcomes, while also ensuring that health services adhere with WHO guidelines. 

Past Projects

Bridging the Gap in HIV testing and care for children in Zimbabwe

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Detect TB

A Cluster randomized trial of two intensified TB case finding strategies in an urban community severely affected by HIV. The study was being conducted in the western part of Harare with the aim of: Providing an extra services to pick up infectious TB more quickly, 

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Zimbabwe National TB Prevalence Survey

To determine the national prevalence of bacteriologically confirmed pulmonary TB in Zimbabwean population aged ≥15years within the period 2013/ 2014

Transmission and Pathogenesis of MDR-TB

Between 2000 and 2006, the estimated global incidence of multidrug-resistant tuberculosis (MDR TB) nearly doubled, and extensively drug-resistant tuberculosis (XDR TB) was newly verified in 49 countries. 

Malaria Research

Our Malaria Research Program aims to support global malaria eradication efforts by developing and deploying innovative tools for improved malaria treatment, prevention and surveillance Recognizing that eradication can only be accomplished by building upon successful local and regional elimination efforts, we work in collaboration with researchers across the globe to train young scientists and clinical investigators, and build research capacity on the ground in malaria-endemic countries.

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ICEMR

Despite the intensified use of Insecticide Residual Spraying (IRS) and Insecticide Treated Nets, parts of Zimbabwe have been experiencing a dramatic rise in numbers of malaria cases, with Manicaland experiencing one of the worst outbreaks. The BRTI, in collaboration with Johns Hopkins Bloomberg School of Public Health, the National Institute for Health Research and the University of the Witwatersrand have established a field site in Mutasa to study different aspects of malaria and the mosquitoes responsible for its transmission.

Other Infectious Diseases

Our Malaria Research Program aims to support global malaria eradication efforts by developing and deploying innovative tools for improved malaria treatment, prevention and surveillance Recognizing that eradication can only be accomplished by building upon successful local and regional elimination efforts, we work in collaboration with researchers across the globe to train young scientists and clinical investigators, and build research capacity on the ground in malaria-endemic countries.

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FIEBRE

FIEBRE is a multi-disciplinary project, led by the London School of Hygiene & Tropical Medicine, that is investigating the leading causes of fever in children and adults attending primary care health services and those admitted to district hospitals in Laos, Malawi, Mozambique, Myanmar and Zimbabwe.

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Antimicrobial Resistance in Gram-negative bacteria from Urinary Specimens: a study of prevalence, risk factors and molecular mechanisms of resistance (ARGUS)

The aims of this study are to determine prevalence of and underlying molecular mechanisms for antimicrobial resistance in gram negative bacteria causing urinary tract infections in Zimbabwe, 

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